Friday, October 13, 2006

Bangladesh banker wins Nobel Peace Prize

Can't argue with a 99% loan repayment rate! There are numerous websites now which allow individuals like you or I to provide micropayment loans to individuals all over the world. One such site is kiva.org...

OSLO, Norway - Bangladeshi economist Muhammad Yunus and the Grameen Bank he founded won the Nobel Peace Prize on Friday for their pioneering use of tiny, seemingly insignificant loans — microcredit — to lift millions out of poverty.

Through Yunus's efforts and those of the bank he founded, poor people around the world, especially women, have been able to buy cows, a few chickens or the cell phone they desperately needed to get ahead.

The 65-year-old economist said he would use part of his share of the $1.4 million award money to create a company to make low-cost, high-nutrition food for the poor. The rest would go toward setting up an eye hospital for the poor in Bangladesh, he said.

The food company, to be known as Social Business Enterprise, will sell food for a nominal price, he said.

"Lasting peace cannot be achieved unless large population groups find ways in which to break out of poverty," the Nobel Committee said in its citation. "Microcredit is one such means. Development from below also serves to advance democracy and human rights."
(..)

Grameen Bank was the first lender to hand out microcredit, giving very small loans to poor Bangladeshis who did not qualify for loans from conventional banks. No collateral is needed and repayment is based on an honor system.

Anyone can qualify for a loan — the average is about $200 — but recipients are put in groups of five and once two members of the group have borrowed money, the other three must wait for the funds to be repaid before they get a loan.

Grameen, which means rural in the Bengali language, says the method encourages social responsibility. The results are hard to argue with — the bank says it has a 99 percent repayment rate.

Since Yunus gave out his first loans in 1974, microcredit schemes have spread throughout the developing world and are now considered a key approach to alleviating poverty and spurring development.

Wednesday, October 11, 2006

Genentech's Profit Climbs 58% Amid Pressure to Pare Drug Prices

The South San Francisco, Calif., biotechnology company yesterday reported net income for the period of $568 million, or 53 cents a share, compared with $359 million, or 33 cents a share, in the year-ago quarter. Revenue rose 36% to $2.38 billion, compared with $1.75 billion.
(..)

Genentech faces challenges on several fronts. Its mainstay colon-cancer drug, Avastin, has demonstrated effectiveness against several forms of cancer, and may be approved for use in lung-cancer patients as early as today. Yet growth in Avastin sales could begin to slow, in part, because cancer specialists

already use the drug against a number of different tumors, limiting its upside.
(..)

Sales of several Genentech drugs, including Avastin, fell slightly short of analyst estimates in the third quarter. The major exception was Lucentis, Genentech's new drug for age-related macular degeneration, which posted sales of $153 million, well above expectations of roughly $30 million.
(..)

Genentech also may face resistance to the price of its drugs. Using Avastin to treat lung cancer requires twice the dose needed in colon cancer, meaning the drug could cost patients or their insurers close to $100,000 a year.


Two weeks ago, Genentech competitor Amgen Inc. announced plans to cap out-of-pocket costs for a cancer drug to 5% of patients' income. Mr. Clark said Genentech was looking into the possibility of expanding a program that assists patients with the cost of drug co-payments, but said the company had no formal announcement yet.

In Brazil, Field Trials To Treat World's Poor


More good work from the Gates Foundation...



The global health community has known for a long time about the wide-ranging complications that hookworm causes, but pharmaceutical companies have had little incentive to develop a vaccine: Most of those infected are too poor ever to pay for medicine, so recovering expensive development costs would be a long shot.
But now the medical ghetto of neglected diseases -- the field concerned with ailments affecting the 2.7 billion people who live on less than $2 a day -- is undergoing a transformation, thanks to an influx of cash from wealthy philanthropists and an emerging development model that promotes public-private partnerships.
(..)

The effects of the funding are hard to miss: Since 1975, only 13 drugs targeting neglected diseases have been launched, according to a study published this year by the London School of Economics and Political Science. But at the end of 2004 alone, 63 projects to develop such drugs were underway, according to the study, and standard attrition rates indicate that eight or nine of those would reach the market.

Although sub-Saharan Africa is generally hit hardest by neglected diseases, Brazil has emerged as an important testing ground for the approach. In addition to the hookworm trial, tests across the country are targeting diseases such as leishmaniasis and schistosomiasis.

FBI Agents Still Lacking Arabic Skills

Article references my good friend Bassem, whom I got to know well when he was stationed as the legal attache in Saudi Arabia--one of the most upstanding individuals I have ever met...
Five years after Arab terrorists attacked the United States, only 33 FBI agents have even a limited proficiency in Arabic, and none of them work in the sections of the bureau that coordinate investigations of international terrorism, according to new FBI statistics.
(..)

Some of the new information about language abilities at the FBI has emerged in connection with a lawsuit by one of the FBI's highest-ranking Arabic speakers, Special Agent Bassem Youssef, who sued the Justice Department and the bureau alleging retaliation after he complained that he was cut out of terrorism cases after the Sept. 11 attacks. Youssef, a naturalized U.S. citizen who was born in Egypt, is one of only six FBI agents who scored a 4 for "advanced professional proficiency" in Arabic on standardized speaking tests administered by the Interagency Language Roundtable for federal agencies. Youssef's attorney, Stephen M. Kohn, said the statistics indicate that most FBI agents have no way to gauge the accuracy of translated materials and must rely on linguists or other third parties for their information. "How do you fight a war with that kind of disadvantage?" Kohn asked.

Across Europe, Worries on Islam Spread to Center - New York Times

This article echoes conversations with numerous individuals last week while in England. The question of reconciliation of Islam and Western values, cultures etc... seems to be on many European's minds at the moment...

Europe appears to be crossing an invisible line regarding its Muslim minorities: more people in the political mainstream are arguing that Islam cannot be reconciled with European values.

Thanks to guest blogger.

Despite guest blogger's busy schedule in medical school, he was able to get up several insightful posts which were much appreciated....If anyone else would like to be a guest blogger or better yet, a coblogger, please let me know!

Why Are They Poor?

A five-part series examines some of the factors impeding development in Africa,

Tuesday, October 10, 2006

Generating Power from Kites

Researchers in Italy have high hopes for a new wind-power generator that resembles a backyard drying rack on steroids. Despite its appearance, the Kite Wind Generator, or KiteGen for short, could produce as much energy as a nuclear power plant.

Jailed for 34 days, Tribune reporter writes: What I saw in Darfur (by Paul Salopek)

A compelling account of a reporter jailed in Darfur...

One cloudless Sunday morning in early August, while traveling on a desert road in the remote Darfur region of western Sudan, a teenager sporting dreadlocks and an AK-47 rifle stopped my vehicle. My translator, Suleiman Abakar Moussa, stepped out and offered the youth a cigarette--standard etiquette in African war zones. But Moussa immediately returned to the car, frowning.

In this incidental way, I learned that we had just lost our freedom.

Monday, October 09, 2006

Conflict Diamonds

Having just returned from Sierra Leone several days ago, diamonds have been on my mind. As oil in Nigeria seems to encourage corruption, diamonds seem to have done the same in Sierra Leone...Here are some current links

ANTWERP, Belgium, Oct 9 (Reuters Life!) - The biggest diamond to be found in 13 years, the "Lesotho Promise," was sold on Monday at auction for more than $12 million and is expected to fetch in excess of $20 million once it is cut up. ADVERTISEMENT The 603-carat (120 gram) diamond, named after the tiny African mountain kingdom where it was found, went under the hammer at the Antwerp Diamond Center and was sold to the South African Diamond Corporation, owner of luxury jewellers Graff.
(I wonder how much money the woman who found the diamond will receive...)



The RUF began its jewelry heist in 1991, using the support of neighboring Liberia to capture Sierra Leone's vast wealth of diamond mines. Since then, the rebels have carried out one of the most brutal military campaigns in recent history, to enrich themselves as well as the genteel captains of the diamond industry living far removed from the killing fields.

The RUF's signature tactic was amputation of civilians: Over the course of the decade-long war, the rebels have mutilated some 20,000 people, hacking off their arms, legs, lips, and ears with machetes and axes. This campaign was the RUF's grotesquely ironic response to Sierra Leone President Ahmad Tejan Kabbah's 1996 plea for citizens to “join hands for peace.” Another 50,000 to 75,000 have been killed. The RUF's goal was to terrorize the population and enjoy uncontested dominion over the diamond fields...

Beginning as early as 1998, the same year Al Qaeda operatives reportedly blew up U.S. embassies in Kenya and Sudan, Osama bin Laden's terrorist network began buying diamonds from the RUF of Sierra Leone, according to FBI sources quoted in the Washington Post.

The paper also reported that two of the Al Qaeda men implicated in those attacks—Ahmed Khalfan Ghailani and Fazul Abdullah Mohammed—were in Sierra Leone in 2001, overseeing RUF diamond production.

As recently as mid-2001, a mere three months before the World Trade Center and Pentagon attacks, Al Qaeda had laundered millions of dollars by buying untraceable diamonds from the rebels. In the wake of Sept. 11, the United States and its allies in the “war on terrorism” froze more than $100 million worth of Al Qaeda assets worldwide. But the terrorists likely have an ace in the hole in the form of diamonds from Sierra Leone, wealth that can be easily and quickly sold and is virtually untraceable....

SURAT: This Christmas, Blood Diamond may take the sheen off Surat’s glittering Rs 45,000-crore gems and jewellery industry. Traders in the city, where 9 of the world’s 11 rough diamonds are cut or polished, fear their business may bleed after the release of Warner Bros’ forthcoming flick Blood Diamond, a film based on a story about the business of 'conflict diamonds' and how its perpetrators used the profits to fund terrorist cells to establish brutal dictatorships in poor African nations.

Breaking the Cycle

A comprehensive article on current attempts at malaria vaccine development with depictions of the sad state of health systems and infrastructure in Eastern Africa...

The U.S. Army and its partners have been trying to develop a malaria vaccine for decades. But given a disease that has thwarted man for centuries and gets scant attention from the West, is this a battle they can win?

Strife lets river blindness regain ground in Africa

YAOUNDE, Sept 21 (Reuters) - Seven years after the World Health Organisation heralded the virtual elimination of river blindness from West Africa, the debilitating disease is regaining ground in several countries due to civil conflict.

"The disease is re-invading some regions where it was thought to have been eradicated," Marcelline Ntep, head of Cameroon's river blindness programme, told Reuters.

She said many of those countries "have been plunged into prolonged civil strife and armed conflicts, thereby interrupting the distribution process and preventing the drug from reaching affected persons in some remote areas."

She cited Liberia, Sierra Leone, Ivory Coast, Central African Republic, Democratic Republic of Congo, Chad, Sudan and the Great Lakes region as areas where the disease had returned.
(..)
The World Health Organisation estimates some 17.7 million people are affected by river blindness, about 90 percent of them in Africa.

In 1974, the international community began the fight against the disease in 11 countries in West Africa, its original home....

Mean Vegetables

Good news. Spinach is safe to eat again, according to the Food and Drug Administration. So dig in if you dare. But beware of carrot juice. Last week, just two days before spinach got the clear, a brand of carrot juice from California was linked to botulism from a bacterium in soil that increases when juice isn’t properly refrigerated.

Maybe you should have some chocolate and red wine instead. Studies in recent years show that they’re linked with phenols that will lower your cholesterol levels.

No need to worry about their extra calories, either. Research from the Centers for Disease Control and Prevention published last spring suggests that overweight people live longer.

And now that a couple stiff drinks a day are deemed good for men’s hearts and Viagra is under study for the same thing, a longer life may be more appealing.

This is becoming the decade when bad is the new good and vice versa.

Sunday, October 08, 2006

Genentech - Lucentis: NIH to fund study vs Avastin

Genentech - Lucentis: NIH to fund study vs Avastin


The "blind greed" saga continues.
The US National Institutes of Health said Thursday that it will fund a study to compare two drugs by Genentech used to treat the leading cause of blindness in the elderly.

One of the drugs, Lucentis, was approved by the FDA this year to treat the disorder, called age-related macular degeneration, or AMD. The other drug, Avastin, which is much cheaper, has been approved to treat colorectal cancer, although it has been widely used off-label to treat the eye condition, according to the NIH's National Eye Institute.

Both drugs are derived from the same mouse antibody.

But....

Genentech are charging around 100 times the price of Avastin for Lucentis!

Insider's view: Way to go NIH!
Drugs firm blocks cheap blindness cure
Genentech continues to try and block use of avastin in the U.K.
Unless Avastin is approved in the UK by the National Institute for Clinical Excellence (Nice) it will not be universally available within the NHS. But because Genentech declines to apply for a licence for this use of Avastin, Nice cannot consider it. In spite of the growing drugs bill of the NHS, it will appraise, and probably approve, Lucentis next year.

Although Nice's role is to look at cost-effectiveness, it says it cannot appraise a drug and pass it for use in the NHS unless the drug is referred to it by the Department of Health. The department says its hands are tied.

"The drug company hasn't applied for it to be licensed for this use. It wouldn't be referred to Nice until they have made the first move," said a Department of Health spokeswoman. "They need to step up and get a licence. If they are not getting it licensed, why aren't they?"

Saturday, October 07, 2006

And his last name is...

Guest blogger, back again. This time I'm going to relay a story told to us in class yesterday. As usual, I'll start out with some background info on a relevant disease.

Loeys-Dietz Syndrome is a recently characterized disease (Nature Genetics 37, 275 - 281, 2005) whose patients were previously considered to have Marfan Syndrome. Loeys-Dietz patients present with, among many other findings, bifid uvula, hypertelorism (widely separated eyes), and a tortuous aorta upon imaging. These patients have a propensity for arterial aneurysm generally; they almost invariably experience aortic root aneurysm, although the timescale is variable (from weeks to decades into life).

A family was kind enough to come to talk about living with Loeys-Dietz (they have a child with the syndrome), and they described difficulties they had had with getting their care providers to understand the disease. Their child, for example, needed surgery. Their doctor, who was with us in the auditorium, had called the surgeon to tell him about the relevant details of Loeys-Dietz in order to maximize the surgery's chance of success. The surgeon blew up at him, screaming, "Who do you think you are that you can lecture me about Loeys-Dietz!?"

The doctor, whose name is Dietz, called this one of his 'greatest moments.' I wish I could have heard the rest of the conversation.

Wednesday, October 04, 2006

HIV+ seeking HIV+

HIV is a diploid retrovirus. Therefore, superinfection of one cell by two strains of HIV can lead to novel recombinant forms of the virus.

Let's say that John has HIV with a genotype of AA. Let's say Jane has HIV with a 'genotype' of BB. Now, if the two exchange HIV via needle sharing or intercourse, some of their cells could become infected by two HIV strains at once. A novel combination of John's and Jane's HIV could result: AB.

This is one mechanism by which resistance to retroviral therapy arises. This pedantic introduction helps to frame the following, otherwise-joyful article in a slightly more sober epidemiological light:


From a HealthGAP posting:
------------------------------------------------
Shunned Indian HIV victims seek infected spouses

Mon 2 Oct 2006 9:08:24 BST
By Rupam Jain Nair

SURAT, India, Oct 2 (Reuters) - Dozens of Indian men and women
infected with HIV/AIDS have agreed to marry each other after meeting
at a special matchmaking event, hoping to end the isolation the
deadly infection often brings.

Thirty infected men and women from across the country met at
the "HIV+ Find a Life Partner" session late on Sunday in the western
city of Surat, brought together by a local voluntary group working
with HIV/AIDS patients.

For over two hours, they shared their experiences, discussed their
families, medical histories and professions, with some even
introducing their prospective partners to accompanying relatives,
before agreeing marry.

"We hope to die on a positive note even though we are infected by
this virus," said Sanjay Joshi, a Surat engineer, who lost his wife
to AIDS four years ago.

Marriage would give him and his partner physical and emotional
support said the 32-year-old man who agreed to marry a HIV infected
woman from southern India and adopt her children.

"Only a HIV-positive person can understand and respect my status. We
are all living with uncertainty every minute. Let us try and enjoy
every bit of life with a companion," said Joshi who has been
ostracised by his parents and friends.

India has the world's highest HIV/AIDS caseload with 5.7 million
infected people. Although the country reported its first case in
1986 most victims face acute stigma due to a lack of awareness and
misconceptions about the disease.

Over the years, the country has reported many instances of families
disowning their loved ones because they are infected, children of
HIV/AIDS patients being thrown out of school, landlords refusing to
rent houses to victims and a infected woman having to abort her own
foetus as doctors shunned her.

HIV/AIDS victims and voluntary groups working with them have been
campaigning for a law to prevent discrimination of patients and
accuse the government of dragging its feet on the legislation.

Daksha Patel, a coordinator at the "Network of Surat People Living
with HIV+", the group which organised the matchmaking event, said
the aim was to bring together as many infected people as possible to
help them find partners.

"Let them find, choose and decide on a partner. It will add a new
spark to the lonely lives and give them a new zest to start all over
again," she said. Patel, who is infected by the virus herself, said
many infected women at Sunday's event were widows or divorcees who
were infected by their husbands and shunned by families.

One such widow, 28-year-old Rani Patel, said she was thrown out by
her in-laws after they found their son had died of AIDS and their
daughter-in-law was infected as well.

"I learnt I was HIV-positive after my husband died," Rani Patel said.

"By marrying again I can create awareness that HIV victims can live
and enjoy a normal life," she said as she attached her photograph to
an application form for a partner.

http://today.reuters.co.uk/news/CrisesArticle.aspx?
storyId=DEL33562&WTmodLoc=World-R5-Alertnet-5

Sorry, I was too busy winning my Nobel Prize

That's right, the mysterious guest blogger is an American. That gives me a one in sixty-million chance of being one of the five Americans who have thus far been awarded the Nobel Prize in 2006. The most recent award in Chemistry went to Roger Kornberg, himself the son of a Nobel Laureate. How did the selection committee do? According to Jeremy Berg, the author of one of the leading biochem textbooks (id est, the one that I use), Kornberg's prize was "fantastically well-deserved."

Kornberg solved the crystal structure of RNA polymerase II in the act of transcribing RNA from DNA. RNApol II primarily transcribes mRNA, the messenger RNA which is later translated by the ribosome into proteins.

Saturday, September 16, 2006

Mysterious Guest Blogger

Well, in twelve hours I will be enroute to Sierra Leone. Fortunately, a very bright individual has agreed to be a guest blogger while I am gone for the next three weeks. I am sure you will enjoy his posts!
Peace

Friday, September 15, 2006

W.H.O. Rules May Increase DDT Use for Malaria

WASHINGTON (AP) -- The World Health Organization on Friday called on more developing countries, particularly in Africa, to begin spraying the controversial pesticide DDT to fight malaria.
(..)

'It's a big change,'' said biologist Amir Attaran of Canada's University of Ottawa, who has long pushed for the guidelines and described a recent draft. ''There has been a lot of resistance to using insecticides to control malaria, and one insecticide especially. ... That will have to be re-evaluated by a lot of people.''

The U.S. government already has decided to pay for DDT and other indoor insecticide use as part of President Bush's $1.2 billion, five-year initiative to control malaria in Africa.

Kochi has positioned indoor spraying as an important but neglected third weapon -- along with insecticide-treated bed nets and new medications -- in the war on malaria, which infects half a billion people each year and kills more than 1 million, most of them children.
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