Thursday, January 15, 2009

Anti-Love Drug May Be Ticket to Bliss


In the new issue of Nature, the neuroscientist Larry Young offers a grand unified theory of love. After analyzing the brain chemistry of mammalian pair bonding — and, not incidentally, explaining humans’ peculiar erotic fascination with breasts — Dr. Young predicts that it won’t be long before an unscrupulous suitor could sneak a pharmaceutical love potion into your drink.

That’s the bad news. The not-so-bad news is that you may enjoy this potion if you took it knowingly with the right person. But the really good news, as I see it, is that we might reverse-engineer an anti-love potion, a vaccine preventing you from making an infatuated ass of yourself. Although this love vaccine isn’t mentioned in Dr. Young’s essay, when I raised the prospect he agreed it could also be in the offing.

Could any discovery be more welcome? This is what humans have sought ever since Odysseus ordered his crew to tie him to the mast while sailing past the Sirens. Long before scientists identified neuroreceptors, long before Britney Spears’ quickie Vegas wedding or any of Larry King’s seven marriages, it was clear that love was a dangerous disease.

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When a female prairie vole’s brain is artificially infused with oxytocin, a hormone that produces some of the same neural rewards as nicotine and cocaine, she’ll quickly become attached to the nearest male. A related hormone, vasopressin, creates urges for bonding and nesting when it is injected in male voles (or naturally activated by sex). After Dr. Young found that male voles with a genetically limited vasopressin response were less likely to find mates, Swedish researchers reported that men with a similar genetic tendency were less likely to get married. In his Nature essay, Dr. Young speculates that human love is set off by a “biochemical chain of events” that originally evolved in ancient brain circuits involving mother-child bonding, which is stimulated in mammals by the release of oxytocin during labor, delivery and nursing.

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