If the findings of existing clinical trials hold up in future research, the potential consequences of this deficiency are likely to go far beyond inadequate bone development and excessive bone loss that can result in falls and fractures. Every tissue in the body, including the brain, heart, muscles and immune system, has receptors for vitamin D, meaning that this nutrient is needed at proper levels for these tissues to function well.
Studies indicate that the effects of a vitamin D deficiency include an elevated risk of developing (and dying from) cancers of the colon, breast and prostate; high blood pressure and cardiovascular disease; osteoarthritis; and immune-system abnormalities that can result in infections and autoimmune disorders like multiple sclerosis, Type 1 diabetes and rheumatoid arthritis.
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Did you know Freedman et al. (2010) have found that serum vitamin D correlates with calcified atheroscleratic plaque?
"Higher levels of 25-hydroxyvitamin D seem to be positively correlated with aorta and carotid CP."
'A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations'
“‘We speculate that recently identified U-shaped relationships between 25OHD concentrations and disease outcomes (i.e. increased risk at both high and low concentrations) may reflect a mixture of genotype-defined subgroups".
'Genetics to Blame for Vitamin D Deficiency?'
"Researchers conducted a genome-wide association study that involved almost 34,000 people of European descent from 15 different studies. They used radioimmunoassay and mass spectrometry to determine vitamin D concentrations and found that variants at three genetic sites, or "loci," were significantly associated with vitamin D concentrations. The presence of harmful alleles at three "loci" more than doubled the risk of Vitamin D insufficiency."
Many people are naturally low in vitamin D, forcing vitamin D levels up by taking supplements can only do harm.
'Common genetic determinants of vitamin D insufficiency: a genome-wide association study' (2010) found none of the genes identified are linked with skin pigmentation, maybe you should think about the fact that the 'experts' like Vieth (the supplement company owner ) assume that skin pigmentation is vitally important.
'Vitamin D deficiency is endemic in Middle Eastern sportsmen.(2010)'
"There was no correlation between 25(OH)D concentration and sunlight exposure, skin coverage and skin colouring."
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