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"In this study we clearly demonstrate that the current use of PAPs in food contact applications does result in human exposure to PFCAs, including PFOA," said Mabury, the lead researcher and a professor in the university's Department of Chemistry.
Elevated levels of PFOA in blood have been associated with changes in sex hormones and cholesterol, according to the U.S. Agency for Toxic Substances. Exposure to PFOA also has resulted in early death and delayed development in mice and rat pups, the agency says.
Rats that ingested PFOA for a long time developed tumors. However, based on differences between rats and humans, scientists have not determined for certain whether this could also occur in humans, the agency says.
"We found the concentrations of PFOA from PAP metabolism to be significant and concluded that the metabolism of PAPs could be a major source of human exposure to PFOA, as well as other PFCAs," said Mabury.
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