The Body Weight-Muscle Mismatch

How muscles recognize changes in body weight — and why sometimes they don’t — are questions that are likely to have relevance for people, and not just lab rats. Studies have found that “individuals who are extremely overweight often complain that moving is difficult,” said James H. Marden, a professor of biology at Penn State and co-author of the rat study. It’s possible that their muscular strength is not keeping pace with their growing body size.
But why there should be such a mismatch between body weight and muscle strength is unknown.